MovDisordV3, Main, Exploration, bibRecord, 003B87

Presynaptic dopaminergic function in patients with restless legs syndrome: Are there common features with early Parkinson's disease?

Identifieur interne : 003B87 ( Main/Exploration ); précédent : 003B86; suivant : 003B88

Presynaptic dopaminergic function in patients with restless legs syndrome: Are there common features with early Parkinson's disease?

Auteurs : Rainer Linke [Allemagne] ; Ilonka Eisensehr [Allemagne] ; Thomas-Christian Wetter [Allemagne] ; Franz-Josef Gildehaus [Allemagne] ; Gabriele Pöpperl [Allemagne] ; Claudia Trenkwalder [Allemagne] ; Soheyl Noachtar [Allemagne] ; Klaus Tatsch [Allemagne]

Source :

Movement Disorders [ 0885-3185 ] ; 2004-10.

RBID : ISTEX:8B66BCA42FF5756E7A7EC5A911A52B0B1C609631

Descripteurs français

Pascal (Inist)
- Homme, Impatience membre inférieur syndrome, Parkinson maladie, Présynaptique, Système nerveux pathologie.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Aged, Corpus Striatum (metabolism), Corpus Striatum (physiopathology), Corpus Striatum (radionuclide imaging), DAT, Diagnosis, Differential, Dopamine (metabolism), Dopamine Plasma Membrane Transport Proteins, Female, Functional Laterality (physiology), Human, Humans, Male, Membrane Glycoproteins (metabolism), Membrane Transport Proteins (metabolism), Middle Aged, Nerve Tissue Proteins (metabolism), Nervous system diseases, Parkinson Disease (diagnosis), Parkinson Disease (metabolism), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, Presynaptic, Putamen (metabolism), Putamen (physiopathology), Putamen (radionuclide imaging), Radiopharmaceuticals (diagnostic use), Receptors, Presynaptic (metabolism), Restless Legs Syndrome (diagnosis), Restless Legs Syndrome (metabolism), Restless Legs Syndrome (physiopathology), Restless legs syndrome, Tomography, Emission-Computed, Single-Photon, dopamine transporter SPECT, restless legs syndrome.
MESH :
- chemical , diagnostic use : Radiopharmaceuticals.
- chemical , metabolism : Dopamine, Membrane Glycoproteins, Membrane Transport Proteins, Nerve Tissue Proteins, Receptors, Presynaptic.
- diagnosis : Parkinson Disease, Restless Legs Syndrome.
- metabolism : Corpus Striatum, Parkinson Disease, Putamen, Restless Legs Syndrome.
- physiology : Functional Laterality.
- physiopathology : Corpus Striatum, Parkinson Disease, Putamen, Restless Legs Syndrome.
- radionuclide imaging : Corpus Striatum, Putamen.
- Aged, Diagnosis, Differential, Dopamine Plasma Membrane Transport Proteins, Female, Humans, Male, Middle Aged, Tomography, Emission-Computed, Single-Photon.

Abstract

The cause of restless legs syndrome (RLS) is unknown, but an involvement of the dopaminergic system and a possible relation to Parkinson's disease (PD) is suggested by the positive response to dopaminergic treatment. We imaged the striatal dopamine transporter with [123I] N‐(3‐iodopropen‐2‐yl)‐2β‐carbomethoxy‐3β‐(chloro‐phenyl) tropane ([123I]IPT) and single‐photon emission computed tomography (SPECT) in 28 RLS patients, and compared the results with transporter binding in 29 patients with early PD and 23 age‐matched controls. No difference in IPT binding was found between RLS patients and controls. IPT binding was correlated significantly with age in RLS patients and controls, whereas there was no relation with the duration of symptoms or severity of RLS. PD patients presented significant lower presynaptic IPT binding ipsi‐ and contralateral to the affected body side compared with RLS patients or controls. We found no common characteristics between RLS patients and patients with early PD detectable by dopamine transporter SPECT. Our results do not strengthen an identical pathophysiologic pathway between RLS and PD on the level of nigrostriatal presynaptic terminal function. © 2004 Movement Disorder Society

Url:

https://api.istex.fr/document/8B66BCA42FF5756E7A7EC5A911A52B0B1C609631/fulltext/pdf

DOI: 10.1002/mds.20226

Affiliations:

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<author><name sortKey="Eisensehr, Ilonka" sort="Eisensehr, Ilonka" uniqKey="Eisensehr I" first="Ilonka" last="Eisensehr">Ilonka Eisensehr</name>
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<term>Corpus Striatum (physiopathology)</term>
<term>Corpus Striatum (radionuclide imaging)</term>
<term>DAT</term>
<term>Diagnosis, Differential</term>
<term>Dopamine (metabolism)</term>
<term>Dopamine Plasma Membrane Transport Proteins</term>
<term>Female</term>
<term>Functional Laterality (physiology)</term>
<term>Human</term>
<term>Humans</term>
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<term>Membrane Glycoproteins (metabolism)</term>
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<term>Parkinson Disease (metabolism)</term>
<term>Parkinson Disease (physiopathology)</term>
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<term>Parkinson's disease</term>
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<term>Putamen (metabolism)</term>
<term>Putamen (physiopathology)</term>
<term>Putamen (radionuclide imaging)</term>
<term>Radiopharmaceuticals (diagnostic use)</term>
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<term>Restless Legs Syndrome (diagnosis)</term>
<term>Restless Legs Syndrome (metabolism)</term>
<term>Restless Legs Syndrome (physiopathology)</term>
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<term>Membrane Transport Proteins</term>
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<term>Restless Legs Syndrome</term>
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<term>Restless Legs Syndrome</term>
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<term>Parkinson Disease</term>
<term>Putamen</term>
<term>Restless Legs Syndrome</term>
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<front><div type="abstract" xml:lang="en">The cause of restless legs syndrome (RLS) is unknown, but an involvement of the dopaminergic system and a possible relation to Parkinson's disease (PD) is suggested by the positive response to dopaminergic treatment. We imaged the striatal dopamine transporter with [123I] N‐(3‐iodopropen‐2‐yl)‐2β‐carbomethoxy‐3β‐(chloro‐phenyl) tropane ([123I]IPT) and single‐photon emission computed tomography (SPECT) in 28 RLS patients, and compared the results with transporter binding in 29 patients with early PD and 23 age‐matched controls. No difference in IPT binding was found between RLS patients and controls. IPT binding was correlated significantly with age in RLS patients and controls, whereas there was no relation with the duration of symptoms or severity of RLS. PD patients presented significant lower presynaptic IPT binding ipsi‐ and contralateral to the affected body side compared with RLS patients or controls. We found no common characteristics between RLS patients and patients with early PD detectable by dopamine transporter SPECT. Our results do not strengthen an identical pathophysiologic pathway between RLS and PD on the level of nigrostriatal presynaptic terminal function. © 2004 Movement Disorder Society</div>
</front>
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<name sortKey="Wetter, Thomas Hristian" sort="Wetter, Thomas Hristian" uniqKey="Wetter T" first="Thomas-Christian" last="Wetter">Thomas-Christian Wetter</name>
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Movement Disorders (revue)

Presynaptic dopaminergic function in patients with restless legs syndrome: Are there common features with early Parkinson's disease?

Presynaptic dopaminergic function in patients with restless legs syndrome: Are there common features with early Parkinson's disease?

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.